Restylane Defyne®

(video “Restylane Defyne” on the DIB‘s youtube channel)

Restylane Defyne®:

The lips and the lines around the mouth, like other areas of the face, show signs of aging as you get older. This often results in lip thinning, lost shape and an increase in vertical lines above the lip.

Restylane Defyne® is a filler that is used for the treatment of moderate to severe smile lines and wrinkles. It is designed specifically to provide natural-looking results in these particular areas by using smaller, smoother hyaluronic acid particles than those used in other Restylane® products.

Treatment Overview

This convenient injectable anti-wrinkle treatment is performed by a highly skilled doctor in the comfort of our office. Typically, the session only takes 15 minutes to a half an hour.

At the start of the Restylane Defyne® session, the targeted areas may be marked to serve as a guide for the injector. Next, the filler injections are delivered into the desired regions. Because Defyne® contains a local anesthetic called lidocaine, the area becomes numb, helping to prevent pain during treatment. In certain cases, a topical anesthetic may also be administered beforehand for further numbing.

Once the filler has been administered and the targeted wrinkles have been addressed, the injector may massage the treated regions. This gentle massaging process ensures even distribution of the Restylane Defyne® filler product.

The Science Behind Restylane Defyne®

Over the years, moderate and severe wrinkles form in the midface area due to the skin’s declining ability to create hyaluronic acid (HA). HA is a substance that keeps the skin tight and is partially responsible for the face’s youthful volume.

To restore hyaluronic acid in the skin tissues, dermatologists inject fillers like Restylane Defyne®. Restylane Defyne® is composed of synthetic hyaluronic acid, making it an ideal filler choice. Once injected, HA bonds with the molecules in the skin tissues, creating instant and lasting volume.

Restylane Defyne® helps cheeks look more youthful by reducing harsh lines. Filling in wrinkles with this popular filler leads to a softer and more youthful appearance. Results look incredibly natural.

The filler is gradually and safely absorbed by the body as the months pass, and its results are usually apparent for around one year or in some cases longer. At this time, patients can return for follow-up treatments to maintain cosmetic results.

Am I a Good Candidate?

Restylane Defyne® is an ideal choice for patients who want to address moderate or harsh midface wrinkles like the nasolabial folds and marionette lines. The nasolabial folds stretch from the corners of the nose to the corners of the mouth, while marionette lines stretch diagonally down from the sides of the mouth.

Most people ages 21 or older are excellent candidates for this injectable filler. If you’re looking for a more youthful aesthetic without undergoing invasive surgery, this soft-tissue dermal filler may be ideal for you.

If you’re allergic to lidocaine or any of the ingredients in Restylane Defyne®, another filler may be a better option for you. Patients with active skin infections will need to treat these issues before filler injections can be performed. Additionally, if you are currently pregnant or breastfeeding, it will be best to wait before coming in for Restylane Defyne®.

Patients who are interested in treating fine lines in areas like the forehead or between the brows are not ideal candidates for Restylane Defyne®. These candidates are recommended to consider one of our many injectable neuromodulator products (Botox®, Dysport®, or Daxxify®).

Why Choose Us for Restylane Defyne®?

The Dermatology Institute of Boston has been named one of the best dermatology practices in Boston. We are conveniently located in the Back Bay near Copley Square to serve our Boston patients.

Our providers are award-winning board-certified dermatologists and members of the American Academy of Dermatology. They are internationally renowned for their knowledge in the field of dermatology.

Our doctors have years of experience in cosmetic dermatology and continue to receive regular training in the latest techniques and advancements. They are also fluent in multiple languages, making it even easier for patients from all walks of life to enjoy our cosmetic services.

Dr. Emmy Graber, the founder of The Dermatology Institute of Boston, is a highly respected medical expert who has shared her expertise on television, in magazines (O Magazine, InStyle Magazine), and on the radio (NPR). Dr. Graber has been published in several medical journals and regularly delivers lectures at events. She has taught students at Northeastern University and Boston University.

Restylane Defyne® Cost

The price of Restylane Defyne® varies depending on several factors. Patients’ aesthetic goals can play a role in determining the overall cost, as can the amount of product administered. It’s best to ask more about the price of your specific treatment during your personalized consultation.

What to Expect During a Consultation for Restylane Defyne®

During your Restylane Defyne® consultation, you’ll meet with one of our experts. They’ll tell you more about the benefits of this filler, along with the details of the treatment process. Feel free to ask questions at any time.

Your expert will also perform a skin examination to ensure that Restylane Defyne® is the right injectable filler for your aesthetic needs and goals. The two of you will discuss your goals, along with your complete medical history. This may include questions regarding allergies, pre-existing health conditions, past procedures and treatments, and current medications and supplements.

Next, your treatment session will be scheduled. You will be advised to avoid using any non-steroidal anti-inflammatory drugs (NSAIDs) in the days prior to your Restylane Defyne® session, since these can increase the risk of exacerbated bleeding and bruising.

Restylane Defyne® Aftercare

Once your injectable treatment session is complete, you’ll be able to go right back to your daily schedule. There’s no need for any recovery time or time off from work.

Avoid sun exposure, heat, pressure, and physically taxing activities like heavy exercise for a couple of days after your Restylane Defyne® treatment session. This will help to preserve your results and prevent exacerbation of any minor side effects.


Restylane Defyne® injections are generally considered to be a low-risk treatment. As with all injection-based procedures, a minor degree of swelling, bruising, and redness is to be expected. These side effects are temporary and will resolve shortly. Precise application of ice packs can aid in resolution of these minor issues.

Learn More Today

To find out more about the benefits of Restylane Defyne®, schedule a consultation at The Dermatology Institute of Boston. Our skilled experts will be happy to answer any questions that you may have. Contact us today!


“Dr. Graber got rid of my skin problem! The medicine that she prescribed was perfect and I appreciate her approachable nature. If I ever have another dermatology issue, I will call her!”

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Many national publications have quoted Dr. Graber and she is a familiar face on local television.
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Important Announcement

Dear Patients,

Our goal here at The Dermatology of Institute of Boston is protect the health of our patients and staff. To continue caring for our patients during these uncertain times, while strictly adhering to the guidelines set by the CDC, we will be only offering virtual consultations. For some patients, an in person visit is best, but if you feel that your concern could be addressed online, this may be a convenient option for you.

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